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Cancer Treatment Nanotechnology Smart

 

The Promise of Photothermal Ablation

and

Hollow Gold Nano-Spheres

 

Smart Technologies' hollow gold nano-spheres (HGN's) is a medical device used in combination with an infrared light source to create heat that destroys solid cancerous tumors. The HGNs are protected from the body's defense systems through PEGylation, a process that hides the HGNs from the body's immune system and is linked via peptide to further increase targeting efficiencies by 10-15 fold. The resulting particles are administered in liquid solution to a patient by intravenous infusion, and accumulate in tumor cells by taking advantage of characteristic leaky blood vessels near the tumor site and by peptide targeting.   The HGNs and infrared light probe must be utilized together, as shown in Figure 1 below. Each component on its own conveys no therapeutic effect.

Figure 1: Photothermal Ablation Mechanism of Action.

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Abstract

 

Provided are novel nanostructures comprising hollow nanospheres (HGNs) and nanotubes for use as chemical sensors, molecular specific photothermal coupling agents, and photothermal ablation compounds. The nanostructures can be used in electromagnetic radiation-induced phototherapy for treatment of cancer and other disorders. The nanostructures can also be used as a sensor that detects molecules. The nanostructures are of particular use in the fields of clinical diagnosis, clinical therapy, clinical treatment, and clinical evaluation of various diseases and disorders, manufacture of compositions for use in the treatment of various diseases and disorders, for use in molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof. The hollow gold nanospheres have a unique combination of spherical shape, small size, and strong, tunable, and narrow surface plasmon resonance absorption covering the entire visible to near IR region.

 

FIELD OF THE INVENTION

 

The present invention relates to novel nanostructures comprising hollow nanospheres or nanoshells and/or nanotubes for use as chemical sensors, molecular specific photothermal coupling agents, and photothermal ablation compounds. The nanostructures can be used in laser- or radiation-induced phototherapy for treatment of cancer and other disorders. The nanostructures can also be used as a sensor that detects molecules. The invention is of particular use in the fields of clinical diagnosis, clinical therapy, clinical treatment, and clinical evaluation of various diseases and disorders, manufacture of compositions for use in the treatment of various diseases and disorders, for use in molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.

 

Drawings

Hollow Gold Nano-Shells

(HGNs)

 

Various Methods of Cancer Treatment

with

Nano-Particles

 

Cancer therapies are currently limited to surgery, radiation, and chemotherapy. All three methods risk damage to normal tissues or incomplete eradication of the cancer. Nanotechnology offers the means to aim therapies directly and selectively at cancerous cells.

 

Nanocarriers

 

Conventional chemotherapy employs drugs that are known to kill cancer cells effectively. But these cytotoxic drugs kill healthy cells in addition to tumor cells, leading to adverse side effects such as nausea, neuropathy, hair-loss, fatigue, and compromised immune function. Nanoparticles can be used as drug carriers for chemotherapeutics to deliver medication directly to the tumor while sparing healthy tissue. Nanocarriers have several advantages over conventional chemotherapy. They can protect drugs from being degraded in the body before they reach their target.

enhance the absorption of drugs into tumors and into the cancerous cells themselves.

allow for better control over the timing and distribution of drugs to the tissue, making it easier for oncologists to assess how well they work.

prevent drugs from interacting with normal cells, thus avoiding side effects.

 

Destruction from within

 

Moving away from conventional chemotherapeutic agents that activate normal molecular mechanisms to induce cell death, researchers are exploring ways to physically destroy cancerous cells from within. One such technology—nanoshells—is being used in the laboratory to thermally destroy tumors from the inside. Nanoshells can be designed to absorb light of different frequencies, generating heat (hyperthermia). Once the cancer cells take up the nanoshells (via active targeting), scientists apply near-infrared light that is absorbed by the nanoshells, creating an intense heat inside the tumor that selectively kills tumor cells without disturbing neighboring healthy cells. Similarly, new targeted magnetic nanoparticles are in development that will both be visible through Magnetic Resonance Imaging (MRI) and can also destroy cells by hyperthermia.

 

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Make a Donation

to

Nano-Particle

Cancer Treatment

Research

 

Smart Technologies and University of California, Santa Cruz is kindly asking for your charitable donations to help us bring a new revolutionary cancer fighting treatment to life. One hunderd percent of your proceeds goes directly to the Nano-Particle Cancer Treatment Research team at the University of California, Santa Cruz, led by Dr. Zhang.  Dr. Zhang and his team are on the forefront of a nano-particle cancer treatment research and have developed a new method for treating cancer with the use of a Gold Hollow Nano-Sphere (HGN). Theses HGNs are a real game changer when it comes to the war on cancer, due to their hollow spherical geometrical properties. These special properties give the HGN the ability to attach to nearly all types of cancer cells as well as mechanism to annihilate them (through a process call thermal oblation). Now with a  revolutionary new cancer treatment prototype in his arsenal, Dr. Zhang and his team need your help to raise 12 million dollars so that they can take this new cancer treatment research technology to FDA clinical trials and get it out of the lab and into the real world. Please help. Together, we can all make a difference and help end the war on cancer. Make your contribution today, save a life tomorrow.

 

Please fill out the form below, and a Smart Technologies representative will contact you on how to proceed with your nano-particle cancer treatment research donation.

 

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Cancer Reduction Success Rate

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Single Cancer Treatment

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Capable Cancer Treatment Target Areas